A cellular model of juvenile idiopathic arthritis
Claire Jiang · Wyckoff, New Jersey
Seventh Place ($70,000) · Regeneron Science Talent Search · 2026
A cell model of juvenile idiopathic arthritis produced by treating rheumatoid arthritis cells with bone morphogenetic protein 4 until they display JIA-like characteristics.
Juvenile disease models are scarce because juvenile tissue is scarce. Deriving one from adult cells is a workaround for a real bottleneck, and the validation is whether the derived cells behave like the disease.
- Rheumatoid arthritis cell culture
- Bone morphogenetic protein 4 treatment
- Phenotype characterisation
- Comparison against JIA characteristics
- When samples for your population do not exist, deriving a model is itself the project
- Every derived model needs an explicit list of the ways it matches and the ways it does not
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