Winning projects

What strong projects actually look like — the question they asked, the design that survived review, and the one decision that made the difference.

Archive entries are summaries compiled for study. Read them for how a project was structured, argued, and defended — not as a template to reproduce. Copying someone else's project is the one thing that will end yours.

1 project

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Total Synthesis of Novel Antivirotics

Adam Kovalčík

Grand award · Regeneron ISEF 2025

Cut the synthesis from 15 steps to 10, roughly doubled yield in less time, and brought the reported cost down from about $75 per gram to about $12.50 per gram.

organic-synthesis
antivirals
green-chemistry
+2

Chemistry