Neural Regeneration Using PGE2 as a Therapeutic
Uma Sthanu · Austin, Texas
Mary Sue Coleman Award for Life Science Innovation & Impact ($10,000) · Regeneron International Science and Engineering Fair · 2025
An investigation of how prostaglandin E2 affects damaged neural cells, aimed at treatments for brain disease and traumatic injury.
Testing an endogenous signalling molecule rather than a novel compound means the safety and pharmacology groundwork already exists. That is a deliberate shortening of the path from result to relevance.
- Neural cell culture
- PGE2 treatment assay
- Damage and regeneration measurement
- Advanced laboratory imaging
- Repurposing a molecule the body already makes skips a large part of the translational argument
- Mechanism-first work is judged on the cleanliness of the assay, not the size of the effect
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