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Winning projects

What strong projects actually look like — the question they asked, the design that survived review, and the one decision that made the difference.

Archive entries are summaries compiled for study. Read them for how a project was structured, argued, and defended — not as a template to reproduce. Copying someone else's project is the one thing that will end yours.

6 projects

advanced

MCMC Sampling of Origami and Linkages

Hikaru Kuribayashi

Grand award · Regeneron ISEF 2026

Simulation software that applies Markov chain Monte Carlo sampling to the configuration space of folded structures and mechanical linkages, exploring many folding states at once instead of following a single path. The intended applications are compact deployable structures such as satellite solar sails and folded medical devices.

  • origami
  • computational-geometry
  • simulation
  • +2
Physics & AstronomyPhysics and Astronomy
advanced

Total Synthesis of Novel Antivirotics

Adam Kovalčík

Grand award · Regeneron ISEF 2025

Cut the synthesis from 15 steps to 10, roughly doubled yield in less time, and brought the reported cost down from about $75 per gram to about $12.50 per gram.

  • organic-synthesis
  • antivirals
  • green-chemistry
  • +2
Chemistry
advanced

Doping in Organic Electrochemical Transistors

Grace Sun

Grand award · Regeneron ISEF 2024

Work on improving organic electrochemical transistors — the switching devices at the heart of flexible bioelectronics — with an eye to sensors and treatment devices for conditions including diabetes, epilepsy and organ failure.

  • organic-electronics
  • transistors
  • bioelectronics
  • +1
Materials Science