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Winning projects

What strong projects actually look like — the question they asked, the design that survived review, and the one decision that made the difference.

Archive entries are summaries compiled for study. Read them for how a project was structured, argued, and defended — not as a template to reproduce. Copying someone else's project is the one thing that will end yours.

18 projects

advanced

A fruit fly model of STAC3 disorder

Ava Grace Cummings

First place · Regeneron STS 2025

Both adult flies and larvae showed improved movement under treatment.

  • rare-disease
  • drosophila
  • myopathy
  • +2
BiologyGenetics
advanced

Pultrusion and Extrusion to Recycle Filament

Benjamin Davis

First place · Regeneron ISEF 2025

Reported about 45% greater efficiency than comparable systems at roughly 90% lower cost.

  • 3d-printing
  • recycling
  • pultrusion
  • +2
EngineeringEngineering Technology: Statics and Dynamics
advanced

Real-Time Assessment of Deteriorative Airborne Risks

Siyaa Poddar

First place · Regeneron ISEF 2025

Low-cost detectors for toxic silica and uranium dust, built from colour-changing chemistry stabilised inside metal-organic frameworks, developed with Indigenous communities near abandoned mines in the US Southwest in mind.

  • air-quality
  • metal-organic-frameworks
  • colorimetric-sensing
  • +2
Materials Science
advanced

Total Synthesis of Novel Antivirotics

Adam Kovalčík

Grand award · Regeneron ISEF 2025

Cut the synthesis from 15 steps to 10, roughly doubled yield in less time, and brought the reported cost down from about $75 per gram to about $12.50 per gram.

  • organic-synthesis
  • antivirals
  • green-chemistry
  • +2
Chemistry
advanced

A bound on similar structures in 3-uniform hypergraphs

Owen Jianwen Zhang

Second place · Regeneron STS 2025

A proof establishing a maximum for how many 3-uniform hypergraphs can share a structure while differing in their connections, resolving a question that had stood open, with applications in computer science.

  • combinatorics
  • hypergraphs
  • extremal-combinatorics
  • +1
Mathematics
advanced

Bacterial transplants to improve sterile male mosquito survival

Logan Lee

Third place · Regeneron STS 2025

Bacterial transplants used to raise the survival rate of sterile male mosquitoes, addressing the weak point of the sterile insect technique: released males that die before they can compete for mates.

  • vector-control
  • mosquitoes
  • microbiome
  • +2
BiologyMicrobiology
advanced

Investigation of Ship Wakes

Aleksandra Petkova

Third place · Regeneron ISEF 2025

A study of how vessel speed shapes wake patterns, combining aerial photography of real wakes with controlled trials using remote-controlled boats, to predict the speed that minimises drag for a given hull size.

  • fluid-dynamics
  • ship-wakes
  • drag
  • +1
Physics & AstronomyPhysics and Astronomy
advanced

Memory and Selfishness in the Prisoners Dilemma

Cory Seelenfreund

Third place · Regeneron ISEF 2025

Simulation and mathematical modelling of how memory length and degree of self-interest change outcomes in the iterated prisoner's dilemma, framed around implications for AI agent design.

  • game-theory
  • prisoners-dilemma
  • agent-based-modelling
  • +1
Mathematics